-
Product Directory
Custom Product
-
Services Offered
Custom Capabilities
-
Sigma
Gabapentin
G154 -
solid
DOWNLOAD MSDS (PDF)Synonym: 1-
CAS Number: 60142-96-3
Empirical Formula (Hill Notation): C9H17NO2
Molecular Weight: 171.24
Beilstein Registry Number: 2359739
EC Number: 262-076-3
MDL number: MFCD00865286
PubChem Substance ID: 24278159
Properties
| Related Categories | Anticonvulsants, Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, G, |
| form | solid |
| color | off-white |
| solubility | H2O: soluble10 mg/mL |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... ADORA1(134), CACNA2D1(781) rat ... Cacna1a(25398) |
Description
Biochem/physiol Actions
Anticonvulsant with unknown mechanism of action; crosses the blood brain barrier; increases GABA concentrations in the brain and reduces excitatory amino acid neurotransmission, perhaps through its effects on voltage-gated calcium channels; exhibits antinociceptive, anxiolytic, neuroprotective and anti-epileptic effects.
Price and Availability
Customers Also Purchased
F0778Felbamate
V8261Vigabatrin
Documents
Certificate of Analysis
| Celltransmissions 19(1) (143 KB ) |
| Gene Information |
| Structure Search |  |
| Similar Products |
Safety Information
| Symbol |   GHS07, GHS08 |
| Signal word | Danger |
| Hazard statements | H315-H319-H335-H360 |
| Precautionary statements | P201-P261-P305 + P351 + P338-P308 + P313 |
| Personal Protective Equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 61-36/37/38 |
| Safety Statements | 53-26-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | GU6496000 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
References
De Sarro, G., et al., Gabapentin potentiates the antiseizure activity of certain anticonvulsants in DBA/2 mice. Eur. J. Pharmacol. 349, 179-185, (1998) Abstract
Gee, N., et al., The novel anticonvulsant drug gabapentin (neurontin) binds to the α2δ subunit of a calcium channel. J. Biol. Chem. 271, 5768, (1996) Abstract
Field, M.J., et al., Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br. J. Pharmacol. 121, 1513-1522, (1997) Abstract
Fink, K., et al., Inhibition of neuronal Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br. J. Pharmacol. 130, 900, (2000) Abstract
Shimoyama, M., et al., Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain 85, 405-414, (2000) Abstract
Taylor, M.T., and Bonhaus, D.W., Allosteric modulation of [3H]gabapentin binding by ruthenium red. Neuropharmacology 39, 1267-1273, (2000) Abstract
Miraucourt LS, Moisset X, Dallel R, Voisin DL, Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia. J. Neurosci., 2519-27, (2005)
Frleta D, Yu CI, Klechevsky E, Flamar AL, Zurawski G, Banchereau J, Palucka AK, Influenza virus and poly(I:C) inhibit MHC class I-restricted presentation of cell-associated antigens derived from infected dead cells captured by human dendritic cells. J. Immunol., 2766-76, (2009) Abstract
Merck 14,4319
Printable Reviews
Share your experience with this product and how it worked in your specific application. We value your opinion and your colleagues will too!
Learn more at www.sigmaaldrich.com/reviews.
Technical Service:
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Bulk Ordering & Pricing:
Need larger quantities for your development, manufacturing or research applications?